Takashi Ikejima Selected Research

Melanoma (Melanoma, Malignant)

1/2017	Timosaponin AIII induces apoptosis and autophagy in human melanoma A375-S2 cells.
9/2014	Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.
7/2013	Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells.
10/2011	Interruption of mitochondrial complex IV activity and cytochrome c expression activated O₂·⁻-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC γ-PKC pathways.
5/2011	Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells.
10/2009	The protective effect of silibinin against mitomycin C-induced intrinsic apoptosis in human melanoma A375-S2 cells.
7/2008	Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling.
1/2008	Nitric oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells.
10/2007	Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis.
9/2007	Silymarin enhanced cytotoxic effect of anti-Fas agonistic antibody CH11 on A375-S2 cells.

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Takashi Ikejima Research Topics

Disease

30	Melanoma (Melanoma, Malignant) 01/2017 - 04/2002
27	Neoplasms (Cancer) 01/2022 - 01/2003
24	Fibrosarcoma 09/2017 - 03/2004
15	Breast Neoplasms (Breast Cancer) 01/2020 - 05/2007
10	Inflammation (Inflammations) 01/2020 - 04/2010
9	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2007 - 01/2003
8	Mitochondrial Diseases (Mitochondrial Disease) 09/2021 - 12/2006
8	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2013 - 01/2007
8	Carcinoma (Carcinomatosis) 09/2012 - 12/2007
7	Lymphoma (Lymphomas) 01/2020 - 03/2005
7	Necrosis 09/2008 - 09/2003
5	Liver Diseases (Liver Disease) 08/2022 - 09/2006
4	Lung Neoplasms (Lung Cancer) 10/2017 - 01/2012
3	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 04/2022 - 01/2019
3	Parkinson Disease (Parkinson's Disease) 11/2021 - 09/2021
3	Neuroinflammatory Diseases 11/2021 - 04/2017
3	Cognitive Dysfunction 09/2021 - 03/2010
3	Fibrosis (Cirrhosis) 01/2020 - 07/2018
3	Type 2 Diabetes Mellitus (MODY) 01/2020 - 06/2018
3	Adenocarcinoma 01/2007 - 03/2004
2	Bites and Stings (Sting) 11/2021 - 01/2021
2	Diabetes Mellitus 08/2018 - 01/2012
2	Alzheimer Disease (Alzheimer's Disease) 04/2018 - 01/2012
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 02/2018 - 01/2018
2	Laryngeal Neoplasms (Laryngeal Cancer) 12/2015 - 08/2010
2	Starvation 09/2014 - 05/2007
2	Pheochromocytoma 09/2012 - 07/2011
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2012 - 01/2012
1	Obesity 01/2022
1	Weight Loss (Weight Reduction) 01/2022
1	Movement Disorders (Movement Disorder) 10/2021

Drug/Important Bio-Agent (IBA)

43	Silybin (Lagosa)IBA 08/2022 - 09/2006
31	oridoninIBA 12/2015 - 06/2004
16	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2013 - 10/2007
14	CaspasesIBA 01/2020 - 09/2003
12	evodiamineIBA 07/2010 - 01/2003
11	Proteins (Proteins, Gene)FDA Link 04/2022 - 12/2006
10	DiterpenesIBA 10/2017 - 06/2004
9	pseudolaric acid BIBA 10/2017 - 12/2004
8	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2014 - 01/2008
5	Biological ProductsIBA 01/2018 - 02/2004
5	FlavonoidsIBA 10/2017 - 07/2004
5	SilymarinIBA 11/2012 - 07/2004
5	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2012 - 02/2007
4	Small Interfering RNA (siRNA)IBA 01/2022 - 01/2019
4	Collagen Type I (Type I Collagen)IBA 01/2022 - 02/2015
4	Amyloid (Amyloid Fibrils)IBA 01/2020 - 07/2011
4	CollagenIBA 11/2019 - 01/2018
4	AcidsIBA 10/2017 - 07/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 12/2005
4	ErbB Receptors (EGF Receptor)IBA 11/2012 - 02/2007
3	Dynamins (Dynamin)IBA 04/2022 - 01/2019
3	Insulin (Novolin)FDA Link 01/2022 - 06/2018
3	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 10/2017
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2021 - 09/2021
3	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 06/2003
3	Phosphotransferases (Kinase)IBA 01/2020 - 04/2005
3	GelatinIBA 11/2019 - 01/2016
3	JNK Mitogen-Activated Protein KinasesIBA 09/2018 - 09/2008
3	physalin AIBA 09/2014 - 05/2013
3	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 11/2013 - 12/2005
3	Cytochromes c (Cytochrome c)IBA 12/2012 - 04/2009
3	norcantharidinIBA 01/2012 - 08/2004
3	Insulin-Like PeptidesIBA 04/2010 - 07/2008
3	Sirtuin 1IBA 03/2007 - 04/2005
2	LipidsIBA 01/2022 - 08/2018
2	InterferonsIBA 11/2021 - 01/2021
2	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 11/2021 - 01/2021
2	mitochondrial transcription factor AIBA 01/2020 - 01/2019
2	PPAR gammaIBA 01/2020 - 01/2019
2	Estrogen Receptor alphaIBA 10/2019 - 07/2015
2	Pattern Recognition ReceptorsIBA 12/2018 - 01/2018
2	Toll-Like Receptor 3IBA 12/2018 - 01/2018
2	RNA (Ribonucleic Acid)IBA 12/2018 - 01/2018
2	bis-benzimidazoleIBA 01/2016 - 10/2012
2	Antineoplastic Agents (Antineoplastics)IBA 12/2015 - 04/2010
2	Caspase 9IBA 12/2015 - 08/2004
2	AntioxidantsIBA 11/2012 - 04/2010
2	RTKI cpdIBA 11/2012 - 08/2010
2	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 09/2012 - 07/2011
2	Mitomycin (Mitomycin-C)FDA LinkGeneric 05/2011 - 10/2009
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 09/2008 - 12/2005
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 09/2008 - 01/2004
2	Sepharose (Agarose)IBA 12/2005 - 08/2005
2	shikoninIBA 04/2005 - 02/2004
1	Long-Acting Thyroid Stimulator (LATS)IBA 01/2022
1	SynucleinsIBA 10/2021
1	Matrix Metalloproteinases (MMPs)IBA 09/2021
1	Cisplatin (Platino)FDA LinkGeneric 01/2021
1	DNA receptor (receptor, DNA)IBA 01/2021
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	Verteporfin (Visudyne)FDA Link 01/2020
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2020
1	Metformin (Glucophage)FDA LinkGeneric 01/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2020

Therapy/Procedure

4	Therapeutics 09/2021 - 05/2008
2	Aftercare (After-Treatment) 04/2009 - 09/2008
1	Traditional Medicine (Folk Remedies) 04/2022
1	Oral Administration 09/2021